環(huán)保在線>產(chǎn)品庫>生物試劑>生物檢測試劑>抗體>>組織型纖溶酶原激活劑抗體TPA

組織型纖溶酶原激活劑抗體TPA

參考價	面議

參考價

面議

具體成交價以合同協(xié)議為準(zhǔn)

公司名稱齊一生物科技（上海）有限公司
品牌
型號
所在地上海市
廠商性質(zhì)生產(chǎn)廠家
更新時間2021/12/23 9:18:54
訪問次數(shù)415

產(chǎn)品標(biāo)簽:

組織型纖溶酶原激活劑抗體 TPA TPA Tissue Plasminogen Activator TPA1 組織型纖溶酶原激活劑抗體TPA

在線詢價收藏產(chǎn)品點(diǎn)擊查看電話

索取相關(guān)資料

公司介紹主營產(chǎn)品

齊一生物科技（上海）有限公司，專業(yè)從事生物產(chǎn)品研發(fā)、生產(chǎn)、經(jīng)營為一體的專業(yè)化生物工程技術(shù)公司！為廣大科研工作者、企業(yè)和學(xué)校提供質(zhì)優(yōu)價廉的實驗室用品，本公司主要經(jīng)營ELISA酶聯(lián)免疫檢測試劑盒、進(jìn)口原裝ELISA試劑盒、分子生物學(xué)檢測試劑盒、免疫學(xué)檢測試劑盒、各品牌*抗體抗原、細(xì)胞菌株、生物培養(yǎng)基、生化試劑、實驗耗材等多門類上萬余種科研試劑產(chǎn)品！產(chǎn)品涉及分子生物學(xué)、細(xì)胞生物學(xué)、免疫學(xué)等生命科學(xué)的各個領(lǐng)域！已迅速發(fā)展成為國內(nèi)科學(xué)試劑的運(yùn)營商之一，是國家重點(diǎn)實驗室*供應(yīng)商，并與國內(nèi)多家科研單位緊密合作。

齊一生物科技（上海）有限公司試劑種類眾多：覆蓋分析化學(xué)品，無機(jī)化學(xué)品，有機(jī)化學(xué)品，生物化學(xué)品，材料化學(xué)品。

本公司代理國外進(jìn)口品牌試劑，具體進(jìn)口品牌有：R&D、IBL、BD、Roche、Sigma、Santa、Tsz、CST、Amresco、Mresco、Sciencell、Immonoway、Wako、Abcam、Merk、Qiagen、ATCC、Axygen、日本同仁、Invitrogen、Gibio、Hyclone、Cloud-clone corp、MP、AddexBi、Novus lifespan Exqion、 GE 、clontech 、 millipore, Jackson、.thermo scientific、Dako Biorbyt 、abbiotech、Supelco 、IBA、Ebioscience、epigentek、Sorenson、Abnova 、Agrisera 、Alfa Aesar、AppliChem、Bender Medsystems、Biodesign、Bio-Rad、BioSource、BioVision、 Inc、Corning、J&K等等。

試劑信息齊全：包含試劑特性描述，詳細(xì)質(zhì)量信息，應(yīng)用方法、標(biāo)準(zhǔn)，用途以及正在開發(fā)的前沿應(yīng)用。

專業(yè)技術(shù)支持：專業(yè)的試劑應(yīng)用范例，應(yīng)用背景，應(yīng)用專題展示，技術(shù)交流。

商務(wù)流程簡潔：網(wǎng)上您了解試劑的所有必須信息，通過電話或電子郵件、網(wǎng)上留言即可以完成商務(wù)，節(jié)約您的寶貴時間，提高您的商務(wù)效率。

到貨快捷安全：專業(yè)的物流配送，專人全程跟蹤訂單，確保貨物安全、準(zhǔn)確、及時地送達(dá)*地點(diǎn)。

齊一生物科技（上海）有限公司以真誠、主動、周到、規(guī)范、熱情的服務(wù)很快得到廣大客戶的*好評。公司秉承“適應(yīng)多樣化的需求，提供專業(yè)化的服務(wù)”的經(jīng)營理念，為客戶提供*的服務(wù)。歡迎社會各界朋友前來洽談業(yè)務(wù)，共創(chuàng)輝煌！

展開顯示更多內(nèi)容

ELISA檢測試劑盒（人，大鼠，小鼠，兔子，牛馬羊，植物，魚，昆蟲），科研生化試劑，標(biāo)準(zhǔn)品，原代細(xì)胞，分子學(xué)試劑盒，生化法檢測試劑盒，進(jìn)口抗體

產(chǎn)品簡介在線詢價

組織型纖溶酶原激活劑抗體TPA研究領(lǐng)域心血管??免疫學(xué)??神經(jīng)生物學(xué)??激酶和磷酸酶??
抗體來源Rabbit
克隆類型Polyclonal
Human,?Mouse,?Rat,?Pig,?Cow,?Horse,?Rabbit,?
WB=1:100-500?ELISA=1:500-1000?IP=1:20-100?IHC-P=1:100-500?IHC-F=1:100-500?IF=1:10

組織型纖溶酶原激活劑抗體TPA 產(chǎn)品信息

組織型纖溶酶原激活劑抗體TPA相關(guān)標(biāo)記   Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5
Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC
英文名稱   TPA
中文名稱   組織型纖溶酶原激活劑抗體
別名   TPA Tissue Plasminogen Activator; Plasminogen activator tissue; Plasminogen activator tissue type; Plasminogen Activator Tissue Type Isoform 1 Preproprotein; PLAT; Reteplase; t PA; t-PA; tPA; T Plasminogen Activator; Tissue plasminogen activator (t PA); PATISS; Tissue type plasminogen activator; TPA; TPA1; AU020998; AW212668; D8Ertd2e; MGC18508; TPA_HUMAN; Tissue-type plasminogen activator; t-plasminogen activator; Alteplase; Tissue-type plasminogen activator chain B.
研究領(lǐng)域   心血管免疫學(xué) 神經(jīng)生物學(xué) 激酶和磷酸酶
抗體來源   Rabbit
克隆類型   Polyclonal
交叉反應(yīng)   Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
組織型纖溶酶原激活劑抗體TPA產(chǎn)品應(yīng)用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量   62kDa
細(xì)胞定位   分泌型蛋白
性狀   Lyophilized or Liquid
濃度   1mg/1ml
免疫原   KLH conjugated synthetic peptide derived from human Tissue-type plasminogen activator chain B
亞型   IgG
純化方法   affinity purified by Protein A
儲存液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件   Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹   background:
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Subunit:
Heterodimer of chain A and chain B held by a disulfide bond. Forms a heterodimer with SERPINA5. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location:
Secreted.

Tissue Specificity:
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Post-translational modifications:
The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.
N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.
Characterization of O-linked glycan was studied in Bowes melanoma cell line.

DISEASE:
Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 fibronectin type-I domain.
Contains 2 kringle domains.
Contains 1 peptidase S1 domain.

Gene ID:
5327

Database links:
Entrez Gene: 5327 Human
Omim: 173370 Human
SwissProt: P00750 Human
Unigene: 491582 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組織型纖溶酶原激活劑tPA是蛋白酶家族的一員,其主要的生物學(xué)功能是激活纖溶酶原轉(zhuǎn)變?yōu)槔w溶酶.
近年來經(jīng)研究表明t-PA參與循環(huán)系統(tǒng)的溶血栓過程之外,t-PA還在神經(jīng)系統(tǒng)中也發(fā)揮了重要的作用，t-PA參與了癲癇和早老型癡呆癥等神經(jīng)系統(tǒng)疾病的發(fā)生和發(fā)展，在學(xué)習(xí)和記憶等生理過程中也發(fā)揮了重要作用。