乙醛脫氫酶2型抗體（）

英文名稱：   Anti-ALDH1A2                            濃度： 1mg/1ml 

抗體來源： Rabbit

克隆類型：polyclonal       

 交叉反應(yīng)： Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Monkey,   

產(chǎn)品類型: 一抗  

性    狀:  Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產(chǎn)品介紹 ：Aldehyde dehydrogenases （ALDHs） mediate NADP+-dependent oxidation of aldehydes into acids during the detoxification of alcohol-derived acetaldehyde; metabolism of corticosteroids, biogenic amines and neurotransmitters; and lipid peroxidation. ALDH1A1, also designated retinal dehydrogenase 1 （RalDH1 or RALDH1）, aldehyde dehydrogenase family 1 member A1, aldehyde dehydrogenase cytosolic, ALDHII, ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid （RA）. There are two major liver isoforms of ALDH1 that can localize to cytosolic or mitochondrial space. The ALDH1A2 （RALDH2, RALDH2-T） gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH1A3 （ALDH6, RALDH3, ALDH1A6） is a 37 kb gene that consists of 13 exons and produces a major transcript of approximay 3.5 kb most abundant in salivary gland, stomach and kidney. ALDH3A1 （stomach type, ALDH3, ALDHIII） forms a cytoplasmic homodimer that preferentially oxidizes aromatic aldehyde substrates. ALDH genes upregulate as a part of the oxidative stress response, and appear to be abundant in certain tumors that have an accelerated metabolism toward chemotherapy agents.

Function : Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.
Subunit : Homotetramer （By similarity）. 
Subcellular Location : Cytoplasm.
Similarity : Belongs to the aldehyde dehydrogenase family.
Database links : UniProtKB/Swiss-Prot: O94788.3