磷酸化腺瘤樣息肉抗體（）
英文名稱： Anti-phospho-APC （Ser2054） 濃度： 1mg/1ml
抗體來源：Rabbit
克隆類型：polyclonal
交叉反應(yīng)： Human,
產(chǎn)品類型: 一抗
性 狀: Lyophilized or Liquid
保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 ：
| Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor （HGF）-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Subcellular Location : Cell junction > adherens junction. Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor （HGF） treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Tissue Specificity : Expressed in a variety of tissues.
Post-translational modifications : Phosphorylated by GSK3B.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.
DISEASE : Defects in APC are a cause of familial adenomatous polyposis （FAP） [MIM:175100]; which includes also Gardner syndrome （GS）. FAP and GS contribute to tumor development in patients with uninherited forms of colorectal cancer. FAP is characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract （ampullary, duodenal and gastric adenomas）. This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years.
Defects in APC are a cause of hereditary desmoid disease （HDD） [MIM:135290]; also known as familial infiltrative fibromatosis （FIF）. HDD is an autosomal dominant trait with * penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis.
Defects in APC are a cause of medulloblastoma （MDB） [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome （Gorlin syndrome）. Defects in APC are a cause of mismatch repair cancer syndrome （MMRCS） [MIM:276300]; also known as Turcot syndrome or brain tumor-polyposis syndrome 1 （BTPS1）. MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.
Defects in APC are a cause of gastric cancer （GASC） [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Defects in APC are a cause of hepatocellular carcinoma （HCC） [MIM:114550]. This defect includes also the disease entity termed hepatoblastoma.
Similarity : Belongs to the adenomatous polyposis coli （APC） family.
Contains 7 ARM repeats.
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卡邁舒（上海）生物科技專業(yè)經(jīng)營一抗二抗,單克隆多克隆抗體,指標(biāo)上千萬種,質(zhì)量好,價格實惠,售后問題負責(zé)到底,
公司對外提供生物技術(shù)外包服務(wù)：
單克隆抗體定制服務(wù)，多克隆抗體定制，單克隆抗體純化 ，多克隆抗體純化 ，
抗體HRP標(biāo)記 ，抗原HRP標(biāo)記 ，抗體膠體金標(biāo)記，抗體FITC標(biāo)記，小鼠單抗Ig類/亞類鑒定，獸用細胞水平檢測（比如干擾素等），多肽半抗原的偶聯(lián)，
親和層析柱制備 （客戶提供抗原抗體）
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