ChAT膽堿乙酰轉(zhuǎn)移酶抗體

相關(guān)標(biāo)記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin   Cy3   Cy5  
Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名稱    ChAT
中文名稱    ChAT膽堿乙酰轉(zhuǎn)移酶抗體
別    名    Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.
研究領(lǐng)域    神經(jīng)生物學(xué)  細(xì)胞類型標(biāo)志物  
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應(yīng)    Human, Mouse, Rat, Dog, Pig, 
產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    68-70kDa
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human ChAT
亞    型    IgG
純化方法    affinity purified by Protein A
儲(chǔ) 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed    PubMed
產(chǎn)品介紹    background:
The neurotransmitter acetycholine is synthesized from choline and acetyl-coA by the choline acetyltransferase (ChAT)enzyme,and a specific marker of cholinergic neurons.The regulation of ChATactivity is thought to be important during the development of nervous systems interactions .The reduction of ChAT activity has been found in several neurodegenerative disorders including Alzheimer’s and amyotrophic lateral sclerosis.

Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

DISEASE:
Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.

Similarity:
Belongs to the carnitine/choline acetyltransferase family.

Gene ID:
1103

Database links:
Entrez Gene: 1103 Human
Entrez Gene: 12647 Mouse
Entrez Gene: 290567 Rat
Omim: 118490 Human
SwissProt: P28329 Human
SwissProt: Q03059 Mouse
SwissProt: P32738 Rat
Unigene: 302002 Human
Unigene: 442817 Mouse
Unigene: 45116 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

膽堿乙酰轉(zhuǎn)移酶（Choline Acetyltransferase，ChAT 又稱為：choline O-Acetyltransferase ,CHOACTase;）是催化膽堿和乙酰*轉(zhuǎn)變?yōu)橐阴：?的一種酶。ChAT有M,S,R三個(gè)亞型，此抗體與三個(gè)亞型都反應(yīng)。