Rabbit anti-Integrin alpha 6/CD 49f
Catalog Number : Rs-2641R
Rabbit anti-Integrin alpha 6/CD 49fQuantity size : 0.2ml （dilute with pH 7.4 0.01 M PBS or antibody diluent ）
Rabbit anti-Integrin alpha 6/CD 49fBackground: Integrins are important extracellular matrix （ECM） receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins （different alpha/ beta subunit combinations） are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis
Rabbit Specificity : · anti- ITGA6 is a rabbit monoclonal antibody unconjugate
· specific for ITGA6 of human, mouse and rat
· epitope mapping near the amino terminus of ITGA6 of human, mouse rat origin
· use for western blotting, elisa, immunoprecipitation and immunohistochemistry
· affinity chromatography purification, purity :>95%
· Isotype: IgG
· mol wt:120kDa
Rabbit Application: ·Western blotting 1:100-500
·Immunohistochemistry 1:100-500
· ELISA 1:500-1000
· Optimal working dilutions must be determined by the end user.
Rabbit Storage: Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least two weeks at 2-4 ºC.
Rabbit Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
