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產(chǎn)品型號Pierce抗體 20398
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更新時間:2023-07-25 07:43:50瀏覽次數(shù):3134次
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Printable Datasheet
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>> See 3 other antibodies for IL33
Entrez Gene ID:
(Human) 90865
UniProt ID:
O95760
Details | |
Host / Isotype: | Rabbit |
Class: | Polyclonal |
Type: | Antibody |
Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) |
Immunogen: | A 19 amino acid peptide from near the center of human IL-33. |
Ordering Information | ||||
Pierce IL-33 Polyclonal Antibody | ||||
Product Number | Pkg. Size | Price | Purchase | |
PA5-20398 | 100 ug | Purchase ? |
Storage: | Stored at -20oC, avoid repeated freeze thaw cycles |
Form: | 100 ug of affinity chromatography purified antibody (1 mg/ml) in PBS containing 0.02% sodium azide. |
Applications | Dilution * |
Western Blot (WB) | 1 ug/ml |
* Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls. |
Product Specific Information |
PA5-20398 targets IL-33 in WB applications and shows reactivity with Human, Murine, and Rat samples. The PA5-20398 immunogen is a 19 amino acid peptide from near the center of human IL-33. |
General Information |
Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1-a/beta, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kappa-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. |
Product Images |
Filter : All ApplicationsWB (1 imgs)
WB using PA5-20398
Western Blot with anti-IL-33 Polyclonal Antibody (PA5-20398)
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Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at (A) 1 and (B) 2 ug/mL.
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WB using PA5-20398
Western Blot with anti-IL-33 Polyclonal Antibody (PA5-20398)
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Western blot analysis of IL-33 in human lymph node tissue lysate with IL-33 antibody at (A) 1 and (B) 2 ug/mL.
... more >>
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