Anti-NR0B1抗體,實(shí)驗(yàn)說(shuō)明腎上腺發(fā)育不全相關(guān)蛋白抗體抗體應(yīng)用于WB、IHC、IF、ELISA等實(shí)驗(yàn)中，產(chǎn)品貨期快、質(zhì)量品牌保障，并提供完善的售前、售中、售后服務(wù)！咨詢或在線客服！我們將竭誠(chéng)為您服務(wù)！公司堅(jiān)持對(duì)產(chǎn)品質(zhì)量作不斷的評(píng)估、創(chuàng)新和改善以確保您對(duì)我們產(chǎn)品的高度信任！
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英文名稱 NR0B1
抗體名稱 Anti-NR0B1抗體,實(shí)驗(yàn)說(shuō)明腎上腺發(fā)育不全相關(guān)蛋白抗體
別    名 NR0B1 / Dax1; AHC; AHCH; AHX; DAX 1; DAX-1; DAX1; Dosage sensitive sex reversal; DSS; DSS AHC critical region on the X chromosome protein 1; DSS-AHC critical region on the X chromosome protein 1; GTD; HHG; Nr0b1; NR0B1_HUMAN; NROB1; Nuclear hormone receptor; Nuclear receptor 0B1; Nuclear receptor DAX 1; Nuclear receptor DAX-1; Nuclear receptor DAX1; Nuclear receptor subfamily 0 group B member 1; SRXY2.  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human NR0B1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

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產(chǎn)品介紹 Adrenal hypoplasia congentia (AHC) is an X-linked disorder characterized by primary adrenal insufficiency. The disorder, which is lethal if untreated, results in adrenal insufficiency early in infancy and is characterized by low serum concentration of glucocorticoids, mineralcorticoids and androgens and failure to respond to ACTH. AHC has been mapped to chromosome Xp21 at the same or close to an X-linked locus involved in sex determination, DSS (for dosage-sensitive sex reversal). The gene corresponding to DSS and AHC (designated DAX-1 for DSS-AHC critical region on the X chromosome, gene 1) has been cloned and shown to be deleted in AHC deletion patients and mutated in AHC non-deletion patients. The carboxy terminal 250 amino acids of the DAX-1-encoded protein, DAX-1, exhibits approximay 50% continuous similarity to the ligand-binding domain of the members of the nuclear hormone receptor superfamily while the amino terminal domain contains a putative DNA-binding motif. DAX-1 binds to retinoic acid responsive elements and down regulates retinoic acid receptor-mediated transcriptional activation.
腎上腺發(fā)育不全相關(guān)蛋白抗體儲(chǔ)存溫度：存在于血清、組織培養(yǎng)上清液或腹水中的抗體在-20℃下能夠*儲(chǔ)存。低溫存放不會(huì)損傷抗體活性?？贵w的工作液通常儲(chǔ)存于4℃中。此溫度下，抗體的活性能穩(wěn)定數(shù)月至數(shù)年亦不損失?？贵w溶液不應(yīng)反復(fù)凍融，因?yàn)榉磸?fù)凍融將導(dǎo)致部分抗體失活并產(chǎn)生不需要的蛋白—蛋白凝聚物?？贵w的凝聚能導(dǎo)致活性喪失。這是由于抗原結(jié)合位點(diǎn)的空間構(gòu)象被破壞，或由于產(chǎn)生的不溶物被離心或過(guò)濾而除去。冷凝蛋白類的抗體不能存放于4℃。因?yàn)樵?℃下此類抗體會(huì)發(fā)生沉淀。一些鼠源性IgG3亞類的抗體有此特性。如果抗體在4℃下發(fā)生沉淀，就應(yīng)該存放于室溫下的疊氮鈉溶液中。
保存條件：低溫
運(yùn)輸：4度，或干冰。
公司抗體具有高純度、高效價(jià)、高特異性的特點(diǎn)，僅用于科學(xué)研究，不可用于臨床診斷及藥物治療，可以應(yīng)用于多種實(shí)驗(yàn)。